Open AccessSerum sclerostin: relation with mortality and impact of hemodiafiltration
Author(s) -
Lotte Lips,
Camiel L.M. de Roij van Zuijdewijn,
Piet M. ter Wee,
Michiel L. Bots,
Peter J. Blankestijn,
Marinus A. van den Dorpel,
Denis Fouque,
Renate de Jongh,
Sandra Pelletier,
Marc Vervloet,
Menso J. Nubé,
Muriël P.C. Grooteman
Publication year - 2016
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfw246
Subject(s) - medicine , quartile , confidence interval , hazard ratio , dialysis , proportional hazards model , sclerostin , cardiology , endocrinology , gene , biochemistry , chemistry , wnt signaling pathway
The glycoprotein sclerostin (Scl; 22 kDa), which is involved in bone metabolism, may play a role in vascular calcification in haemodialysis (HD) patients. In the present study, we investigated the relation between serum Scl (sScl) and mortality. The effects of dialysis modality and the magnitude of the convection volume in haemodiafiltration (HDF) on sScl were also investigated.
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