Open AccessAPOL1nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans
Author(s) -
Orlando M. Gutiérrez,
Suzanne E. Judd,
Marguerite R. Irvin,
Degui Zhi,
Nita A. Limdi,
Nicholette D. Palmer,
Stephen S. Rich,
Michèle M. Sale,
Barry I. Freedman
Publication year - 2015
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfv229
Subject(s) - medicine , nephropathy , apolipoprotein b , lipoprotein , high density lipoprotein , gene , endocrinology , genetics , bioinformatics , cholesterol , diabetes mellitus , biology
Two independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial. Although APOL1 binds plasma high-density lipoproteins (HDLs), data on APOL1 risk variant associations with HDL subfractions are sparse.
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