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Weight slope 2 (for each 1 kg/month increase) 0.72 [0.61 ; 0.85] <0.001 0.73 [0.62 ; 0.85] <0.001 Fistula (vs Catheter) 0.39 [0.25 ; 0.60] <0.001 0.36 [0.23 ; 0.57] <0.001 Active malignancy (Yes) 1.82 [1.12 ; 2.95] 0.02 1.95 [1.20 ; 3.18] 0.01 Chronic resp. disease (Yes) 2.05 [1.36 ; 3.09] <0.001 1.92 [1.26 ; 2.93] 0.002 Myocardial infarction (Yes) 0.82 [0.48 ; 1.41] 0.5 0.74 [0.42 ; 1.30] 0.3 Diabetes (Yes) 0.92 [0.64 ; 1.32] 0.7 0.87 [0.60 ; 1.25] 0.5 Emergency start (Yes) 0.94 [0.64 ; 1.39] 0.8 0.83 [0.56 ; 1.24] 0.4 Coronary failure (Yes) 1.34 [0.94 ; 1.90] 0.1 1.15 [0.80 ; 1.66] 0.5 Stroke (Yes) 1.20 [0.68 ; 2.13] 0.5 0.99 [0.55 ; 1.77] 0.9 Peripheral vascular disease (Yes) 1.80 [1.26 ; 2.56] 0.001 Dysrhythmia (Yes) 1.86 [1.29 ; 2.70] 0.001 Results from Cox regression models adjusting on age, gender and study center. PATIENTS. Patients incident to hemodialysis in 20042010 in 2 centers (NDSG, Sète; NéphroCare, Castelnaule-Lez) and surviving 90 days were followed-up for up to until December 31st, 2011 (up to 8 years). OUTCOME. Comorbidities and outcome (deaths or dialysis refusal) were obtained from the French REIN registry. EXPOSURE. BW and BP observed over the initial 90 days on dialysis were obtained from dialysis records. Estimated baseline level and slopes of change in predialysis BP and BW were obtained using mixed linear models allowing for a change of slope after one month on dialysis. Associations with outcome were assessed by Cox regression models.

FP699LOW BLOOD PRESSURE AND MARKED WEIGHT LOSS IN INCIDENT DIALYSIS PATIENTS ARE ASSOCIATED WITH HIGH MORTALITY