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and Aims: Diabetic nephropathy(DN) is a low grade inflammatory disease trigged by metabolic disorder. Inflammation has played an important role in the early stage of DN pathogenesis. Inflammatory cytokines, such as C-reactive protein (CRP), have contributed to inflammation through binding immunoglobulin G Fc receptors (FcγRs)in the surface of cell. We previously found that the expression of FcγRs with an immunoreceptor tyrosine-based activation motif(ITAM-FcγRs) increased in the kidney of diabetic CRP-Tg mouse induced by STZ. The present study investigated the potential role of ITAM-FcγRs in the early stage of DN.

FP461IMMUNOGLOBULIN G FC RECEPTORS WITH AN IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF PROMOTES DIABETIC NEPHROPATHY IN THE EARLY STAGE