Open AccessMisdiagnosing renal amyloidosis as minimal change disease
Author(s) -
Rabya Sayed,
Janet A. Gilbertson,
David F. Hutt,
Helen J. Lachmann,
Philip N. Hawkins,
Paul Bass,
Julian D. Gillmore
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu242
Subject(s) - pathognomonic , medicine , amyloidosis , pathology , nephrotic syndrome , congo red , amyloid (mycology) , minimal change disease , histology , kidney disease , kidney , glomerulonephritis , disease , gastroenterology , focal segmental glomerulosclerosis , adsorption , organic chemistry , chemistry
Minimal change disease (MCD) accounts for 10-15% of all adult nephrotic syndrome cases and requires normal renal histology by light microscopy and negative immunohistology. Foot process effacement on electron microscopy (EM) is typical. Renal amyloid deposits demonstrate pathognomonic green birefringence when viewed under cross-polarized light after staining tissue with Congo red (CR) and may reveal fibrils on EM. Late diagnosis and delayed treatment of renal amyloidosis negatively impact on renal and patient survival.
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