Open AccessMouse model of proximal tubule endocytic dysfunction
Author(s) -
Kathrin Weyer,
Tina Storm,
Jerry W. Shan,
Seppo Vainio,
Renata Kozyraki,
P Verroust,
Erik Christensen,
Rikke Nielsen
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr525
Subject(s) - medicine , endocytic cycle , proximal tubule , renal tubule , microbiology and biotechnology , endocytosis , kidney , receptor , biology
Several studies have indicated the central role of the megalin/cubilin multiligand endocytic receptor complex in protein reabsorption in the kidney proximal tubule. However, the poor viability of the existing megalin-deficient mice precludes further studies and comparison of homogeneous groups of mice.
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