Open AccessToll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells
Author(s) -
Gang Chen,
Hong Wu,
Jin Ma,
Steven J. Chadban,
Alexandra F. Sharland
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr234
Subject(s) - tlr4 , receptor , medicine , toll like receptor , kidney , inflammation , chemokine , immunology , microbiology and biotechnology , cancer research , biology , innate immune system
Engagement of Toll-like receptor (TLR) 4 on intrinsic kidney cells is critical for the full development of renal ischaemia-reperfusion injury (IRI). Effects of TLR signalling in renal parenchymal cells include the production of cytokines, chemokines and other soluble mediators which contribute to local inflammation and leucocyte accumulation. Whether engagement of TLR4 on kidney cells results in additional pro-inflammatory modifications of the renal microenvironment remains to be determined.
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