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chronic hemodialysis patient? Sodium. Semin Dial 2008; 21: 226–229 14. Burnett RW, Covington AK, Fogh-Andersen N et al. Use of ionselective electrodes for blood—electrolyte analysis. Recommendations for nomenclature, definitions and conventions. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Scientific Division Working Group on Selective Electrodes. Clin Chem Lab Med 2000; 38: 363–370 15. Cristol JP, Balint B, Canaud B et al. Sodium determination in biological fluids. Nephrol Ther 2007; 3Suppl 2S104–S111 16. Bourque CW. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci 2008; 9: 519–531 17. Hecking M, Kainz A, Horl WH et al. Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gain. Am J Nephrol 2011; 33: 39–48 18. Santos SFF, Peixoto AJ. Revisiting the dialysate sodium prescription as a tool for better blood pressure and interdialytic weight gain management in hemodialysis patients. Clin J Am Soc Nephrol 2008; 3: 522–530 19. Edelman IS, Leibman J, O’Meara MP et al. Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest 1958; 37: 1236–1256 20. Titze J. Water-free sodium accumulation. Semin Dial 2009; 22: 253–255 21. Titze J, Bauer K, Schafflhuber M et al. Internal sodium balance in DOCA-salt rats: a body composition study. Am J Physiol Renal Physiol 2005; 289: F793–F802 22. Titze J, Shakibaei M, Schafflhuber M et al. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol 2004; 287: H203–H208 23. Shaldon S. Beneficial effect of strict volume control on blood pressure and mortality in patients on hemodialysis. Nat Clin Pract Nephrol 2007; 3: 130–131 24. Farmer CKT, Donohoe P, Dallyn P et al. Low-sodium haemodialysis without fluid removal improves blood pressure control in haemodialysis patients. Nephrology 2000; 5: 237–241

The never-ending search for the perfect dialysis. Should we move from the best treatment to the best system?