Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats | Zendy

Taketoshi Kushiyama | Zendy; Oda T | Zendy; M. Yamada | Zendy; Koichi Higashi | Zendy; Kenji Yamamoto | Zendy; Naoki Oshima | Zendy; Yutaka Sakurai | Zendy; Susumu Miura | Zendy; Hiromichi Kumagai | Zendy

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Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats

Author(s) -

Taketoshi Kushiyama,

Oda T,

M. Yamada,

Koichi Higashi,

Kenji Yamamoto,

Naoki Oshima,

Yutaka Sakurai,

Susumu Miura,

Hiromichi Kumagai

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr068

Subject(s) - medicine , peritoneum , peritoneal dialysis , fibrosis , intraperitoneal injection , peritoneal cavity , macrophage , chlorhexidine gluconate , endocrinology , pathology , surgery , in vitro , biochemistry , biology , dentistry , chlorhexidine

Long-term peritoneal dialysis (PD) causes morphologic and functional changes in the peritoneum that hamper the continuation of PD therapy. Because macrophages play important roles in the development of peritoneal fibrosis and liposome-encapsulated clodronate (LC) induces macrophage apoptosis, we examined the effect of LC on chlorhexidine gluconate (CG)-induced peritoneal fibrosis in rats.

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