Open AccessGlomerular haematuria, renal interstitial haemorrhage and acute kidney injury
Author(s) -
Catalina Martín Cleary,
Juan Antonio Moreno,
B. Fernandez,
Alberto Ortíz,
Emilio González Parra,
C. Gracia,
Luis Miguel BlancoColio,
A. Barat,
Jesús Egido
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq493
Subject(s) - medicine , acute kidney injury , extravasation , pathology , cd163 , kidney disease , nephropathy , kidney , hemosiderin , kidney glomerulus , glomerulonephritis , macrophage , endocrinology , diabetes mellitus , in vitro , chemistry , biochemistry
Macroscopic haematuria of glomerular origin has been associated with acute kidney injury. We report a patient with IgA nephropathy, macroscopic haematuria and acute kidney injury. Systemic anticoagulation may have aggravated haematuria. There was extensive interstitial and intratubular red blood cell extravasation, and interstitial haemosiderin deposits. The abundant presence of macrophages expressing the haemoglobin scavenger receptor CD163 and of cells stained for oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) in areas of interstitial haemorrhage and red blood cell cast-containing tubules provided evidence for a role for free haemoglobin in tubulointerstitial renal injury in human glomerular disease.
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