Open AccessCarbamazepine can induce kidney water absorption by increasing aquaporin 2 expression
Author(s) -
Ana Carolina de Bragança,
Z. P. Moyses,
Antônio J. Magaldi
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq317
Subject(s) - medicine , carbamazepine , aquaporin 2 , kidney , aquaporin , aquaporin 1 , kidney disease , pharmacology , absorption (acoustics) , water channel , physiology , psychiatry , inlet , physics , acoustics , epilepsy , engineering , mechanical engineering
Carbamazepine (Carba) is an anticonvulsant and psychotropic drug used widely for the treatment of intellectual disability and severe pains, but the incidence of hyponatremia is a common related occurrence. This hyponatremia is frequently attributed to a SIADH induced by this drug. It is also known that Carba is used to decrease the urinary volume in Diabetes Insipidus (DI) because it has an antidiuretic effect. Lithium (Li) is one of the most important drugs used to treat bipolar mood disorders. However Li has the undesirable capacity to induce DI. Nowadays, the association of these drugs is used in the treatment of patients with psychiatric and neurological problems.
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