Open AccessMineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats
Author(s) -
Hiroo Kawarazaki,
Kentaro Ando,
Akiko NAGAE,
Megumi Fujita,
Hiromitsu Matsui,
Toshiro Fujita
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq197
Subject(s) - endocrinology , medicine , mineralocorticoid receptor , eplerenone , hydralazine , renal function , aldosterone , mineralocorticoid , blood pressure
Excessive prepubertal salt intake permanently increases blood pressure (BP). We examined the role that the mineralocorticoid receptor (MR) plays in the salt-induced hypertension and renal damage of prepubertal Dahl salt-sensitive (SS) rats.
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