Open AccessExpression and function of matrix Gla protein in human peritoneal mesothelial cells
Author(s) -
Yanhua Zhai,
Liangyi Chen,
Meike Hömme,
Thilo Hackert,
M.-L. Gross,
G. F. Hoffmann,
F. Schaefer,
Claus Peter Schmitt
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq190
Subject(s) - matrix gla protein , mesothelial cell , ectopic calcification , calcification , calcium , western blot , osteopontin , medicine , microbiology and biotechnology , peritoneum , endocrinology , biology , biochemistry , pathology , gene
Chronic peritoneal dialysis (PD) is associated with peritoneal calcification. Studies in vascular tissue suggest that ectopic calcification is not merely a passive but a regulated process resembling bone mineralization. We investigated whether peritoneal calcification is controlled by matrix Gla protein (MGP) secreted by peritoneal mesothelial cells.
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