Open AccessPlasma and urine leukocyte elastase- 1protease inhibitor complex as a marker of early and long-term kidney graft function
Author(s) -
M Zynek-Litwin,
J Kuźniar,
Zofia Marchewka,
Wiesław Kopeć,
Mariusz Kusztal,
Leszek Patrzałek,
Przemysław Biecek,
Marian Klinger
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq041
Subject(s) - medicine , kidney transplantation , degranulation , kidney , elastase , renal function , neutrophil elastase , urine , immunology , pathology , inflammation , receptor , enzyme , biochemistry , chemistry
Neutrophils are mediators of ischaemia/reperfusion (I/R) injury following kidney transplantation (kTx). Leukocyte elastase (LE) complex with alpha(1)protease inhibitor (LE-alpha(1)PI) is a marker of neutrophil degranulation. The aim of this study was to evaluate LE-alpha(1)PI as a marker of I/R kidney damage and to search for correlations between leukocyte activation and post-transplant complications.
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