Open AccessThe mitogen-activated protein kinase Erk5 mediates human mesangial cell activation
Author(s) -
F. Dorado,
S. Velasco,
Azucena EsparísOgando,
Miguel Pericacho,
Atanasio Pandiella,
J. Silva,
José M. LópezNovoa,
Alicia RodríguezBarbero
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn333
Subject(s) - mesangial cell , microbiology and biotechnology , growth factor , epidermal growth factor , mapk/erk pathway , kinase , signal transduction , cell growth , biology , cell culture , medicine , endocrinology , kidney , receptor , biochemistry , genetics
Mesangial activation occurs in many forms of renal disease that progress to renal failure. Mitogen-activated protein kinases (MAPKs) are important mediators involved in the intracellular network of interacting proteins that transduce extracellular stimuli to intracellular responses. The extracellular signal-regulated kinases 5 (Erk5) MAPK pathway has been involved in regulating several cellular responses. Thus, we examined the expression of Erk5 in human renal tissue and the function of Erk5 in cultured human mesangial cells.
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