Open AccessBacterial DNA and endothelial damage in haemodialysis patients
Author(s) -
Ana Merino,
Sonia Nogueras,
Tania García-Maceira,
Mariano Rodríguez,
Alejandro MartínMalo,
Rafael Ramı́rez,
Julia Carracedo,
Pedro Aljama
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn308
Subject(s) - cd14 , cd16 , medicine , peripheral blood mononuclear cell , monocyte , immunology , flow cytometry , apoptosis , biology , immune system , cd8 , biochemistry , in vitro , cd3
An increased percentage of CD14+CD16+ activated monocytes have been reported in peripheral blood from haemodialysis patients. The aim of this study is to investigate if a mild stimulus such as bacterial DNA (CpG-ODNs) contamination may induce an inflammatory response in CD14+CD16+ monocytes from haemodialysis patients and to value the biological consequences of this inflammatory response on endothelial cell damage.
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