Open AccessPAI-1 donor polymorphism influences long-term kidney graft survival
Author(s) -
Jean-Philippe Rérolle,
E. Munteanu,
M Drouet,
Jean-Christophe Szelag,
B. Champtiaux,
Fatima Yagoubi,
PierreMarie Preux,
JeanClaude Aldigier,
Yannick Le Meur
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn241
Subject(s) - medicine , genotype , plasminogen activator inhibitor 1 , kidney , gastroenterology , plasminogen activator , haplotype , fibrosis , kidney transplantation , kidney disease , gene , biology , genetics
The type 1 plasminogen activator inhibitor (PAI-1) is involved in the development of fibrosis, and its intrarenal expression is increased in interstitial fibrosis and tubular atrophy (IFTA). Moreover, a 4G/5G polymorphism of the PAI-1 gene has been described associating 4G haplotype with higher PAI-1 plasma activity. We investigated the relationship between the donor and recipient PAI-1 polymorphism and kidney graft survival.
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