Open AccessDifferent renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats
Author(s) -
Núria Lloberas,
Josep Torras,
Gabriela Alperovich,
Josep M. Cruzado,
Pepita GimenezBonafé,
I. Herrero,
Marcella Franquesa,
Inés Rama,
J.M. Grinyó
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn223
Subject(s) - tacrolimus , medicine , sirolimus , nephrotoxicity , calcineurin , toxicity , renal function , urology , kidney , atrophy , pharmacology , saline , endocrinology , transplantation
The association of calcineurin inhibitors (CNIs) with mTOR inhibitors (mTORi) is still a problem in clinical practice and there is substantial interest in better understanding the impact of these associations on kidney toxicity. We aimed to analyse the functional and histological profiles of damage and to define the contribution of inflammatory and pro-fibrotic mediators in the association of cyclosporine (CsA) and/or tacrolimus (Tac) with sirolimus (SRL).
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