Open AccessRenoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats
Author(s) -
Femke Waanders,
Ellen van den Berg,
Ryoji Nagai,
Isa van der Veen,
Gerjan Navis,
Harry van Goor
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm589
Subject(s) - medicine , endocrinology , transplantation , glomerulosclerosis , renal function , nephropathy , proteinuria , diabetic nephropathy , fibrosis , nephrology , urology , kidney , diabetes mellitus
Advanced glycation end products (AGEs) are involved in diabetic nephropathy (DN). The AGE formation inhibitor pyridoxamine (PM) is renoprotective in DN and in normoglycaemic obese Zucker rats. In chronic allograft nephropathy (CAN), renal AGE accumulation occurs as well.
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