Combined effects of moderately elevated blood glucose and locally produced TGF- 1 on glomerular morphology and renal collagen production | Zendy

Søren Krag | Zendy; Jens R. Nyengaard | Zendy; Lise Wogensen | Zendy

Open Access

Combined effects of moderately elevated blood glucose and locally produced TGF- 1 on glomerular morphology and renal collagen production

Author(s) -

Søren Krag,

Jens R. Nyengaard,

Lise Wogensen

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm229

Subject(s) - medicine , endocrinology , extracellular matrix , kidney , tissue inhibitor of metalloproteinase , immunostaining , transforming growth factor , matrix metalloproteinase , blood urea nitrogen , immunohistochemistry , biology , microbiology and biotechnology

There is a correlation between renal graft rejection and blood glucose (BG) levels. Furthermore, diabetic patients may develop non-diabetic renal diseases, which in some circumstances progress rapidly. Since transforming growth factor-beta1 (TGF-beta) levels are elevated in many renal diseases, the accelerated progression may be due to interactions between glucose and locally produced TGF-beta1. Therefore, we investigated the effect of mild hyperglycaemia on glomerular morphology and collagen production in TGF-beta1 transgenic mice.

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