Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells | Zendy

Kazuhiro Shiizaki | Zendy; Naohiko Hayakawa | Zendy; Ikuo Imazeki | Zendy; Ikuji Hatamura | Zendy; Tadashi Okada | Zendy; Shigeo Negi | Zendy; Takeshi Sakaguchi | Zendy; Takashi Shigematsu | Zendy; Tadao Akizawa | Zendy

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Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells

Author(s) -

Kazuhiro Shiizaki,

Naohiko Hayakawa,

Ikuo Imazeki,

Ikuji Hatamura,

Tadashi Okada,

Shigeo Negi,

Takeshi Sakaguchi,

Takashi Shigematsu,

Tadao Akizawa

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl713

Subject(s) - parathyroid gland , calcitriol , calcitriol receptor , secondary hyperparathyroidism , medicine , vitamin d and neurology , receptor , hyperparathyroidism , vitamin , endocrinology , parathyroid chief cell , parathyroid hormone , calcium , nuclear medicine

Injection of maxacalcitol (OCT) directly into the parathyroid gland (PTG) is a clinically safe and effective treatment for advanced secondary hyperparathyroidism (A-SHPT) resistant to conventional medical treatment. In the present study, the degree of nuclear localization of directly injected OCT in parathyroid cells (PTC) was investigated by microautoradiography (mARG) in a model of A-SHPT.

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