Open AccessRenoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes
Author(s) -
SooYoun Lee,
Wonsuk Kim,
S.-O. Moon,
Moo Je Sung,
D. H. Kim,
Kyung Pyo Kang,
Kyu Yun Jang,
SangYun Lee,
B. H. Park,
Gou Young Koh,
S. K. Park
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl598
Subject(s) - medicine , endocrinology , diabetic nephropathy , angiopoietin , podocyte , monocyte , inflammation , vascular endothelial growth factor , diabetes mellitus , kidney , vegf receptors , proteinuria
Inflammatory processes have been recently seen as underlying the pathogenesis of diabetic nephropathy. Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability and inflammation. We have developed a soluble, stable and potent Ang1 variant, cartilage oligomeric matrix protein (COMP)-Ang1.
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