Open AccessCyclosporine A induced epithelial–mesenchymal transition in human renal proximal tubular epithelial cells
Author(s) -
Tara McMorrow,
Michelle M. Gaffney,
Craig Slattery,
Eric L. Campbell,
Michael P. Ryan
Publication year - 2005
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh967
Subject(s) - epithelial–mesenchymal transition , medicine , mesenchymal stem cell , kidney , fibrosis , downregulation and upregulation , embryonic stem cell , epithelium , cancer research , pathology , complication , biology , cancer , metastasis , biochemistry , gene
Tubulointerstitial fibrosis is a relatively common and sinister complication of cyclosporine A (CsA) therapy that limits its clinical use. CsA may have direct effects on renal tubular epithelial cells by promoting epithelial-mesenchymal transition (EMT). EMT plays an important role in embryonic development and tumourigenesis and has been described in organ remodelling during fibrogenesis. In this study, we investigated the effects of CsA on a human renal cell line as a model system to test the hypothesis that CsA can induce renal EMT.
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