Open AccessCyclosporin exposure correlates with 1 year graft function and histological damage in renal transplanted patients
Author(s) -
Paolo Sacchi,
Annalisa Teutonico,
Giovanni Stallone,
Barbara Infante,
Antonio Schena,
Giuseppe Grandaliano,
Michele Battaglia,
P. Ditonno,
Paolo F. Schena
Publication year - 2004
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh344
Subject(s) - medicine , renal function , urology , creatinine , transplantation , kidney disease , kidney transplantation , biopsy , incidence (geometry) , gastroenterology , kidney , surgery , optics , physics
Cyclosporin (CsA) level obtained 2 h after the morning dose (C(2)) has been shown to accurately predict total CsA exposure and acute rejection (AR) risk, whereas conventional trough levels (C(0)) do not. The impact of C(2) monitoring on long-term kidney graft function, independent from AR risk, is still unclear, however, and it was assessed in the present study.
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