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approach in a haemodialysis patient with very severe clinical manifestations of the disease, which led her to attempt suicide. In this unblinded single patient we cannot exclude a placebo effect, which can be particularly relevant in patients with pruritus. However, no placebo effect could be observed with all the other treatments (antihistamines, steroids and UVB light) carried out in this patient. In addition, a consistent pharmacological effect from cyclosporin is indicated by the response to challenge, withdrawal and rechallenge. Although the potential side effects of an immunosuppressive drug in dialysis patients should be kept in mind, our results indicate that cyclosporin treatment might be a new effective approach to severe uraemic pruritus refractory to conventional treatment modalities, provided that appropriate patients are selected and careful monitoring is performed. Our observation and hypothesis need to be confirmed by a placebo-controlled double-blind trial.

Treatment of digoxin intoxication model by hybrid-kidney with hollowfibre module for clinical haemodialysis