Open AccessPitfalls of single-sample determination of renal clearance
Author(s) -
Sabine Zitta
Publication year - 2002
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.12.2239
Subject(s) - renal function , sample (material) , clearance , medicine , sample size determination , metabolic clearance rate , kinetics , effective renal plasma flow , chromatography , function (biology) , identification (biology) , renal blood flow , urology , statistics , mathematics , chemistry , pharmacokinetics , biology , botany , quantum mechanics , physics , evolutionary biology
Single-sample techniques are widely used for determination of renal clearance by elimination kinetics of radiolabelled marker substances. Frequently, however, formulae for transforming single-time measurement values into estimates of kinetic function, such as renal clearance, are being established exclusively by data reduction methods and are devoid of any physiological meaning.
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