Open AccessAdvanced glycation and lipoxidation end products: reactive carbonyl compounds‐related uraemic toxicity
Author(s) -
Toshio Miyata,
Akira Saitō,
Kiyoshi Kurokawa,
Charles van Ypersele de Strihou
Publication year - 2001
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/16.suppl_4.8
Subject(s) - glycation , medicine , amyloidosis , pathogenesis , biochemistry , enzyme , uremia , toxicity , chemistry , immunology , endocrinology , diabetes mellitus
Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.
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