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An XbaI polymorphism in the gene encoding the glucose transporter, GLUT-1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients. In addition, an amino acid variant (K121Q) in the gene encoding the glycoprotein plasma cell differentiating antigen (PC-1), a specific inhibitor of insulin receptor signalling, has been reported to predict a faster progression of nephropathy in Italian and British type 1 diabetic patients.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

Diabetic microvascular complications are not associated with two polymorphisms in the GLUT‐1 and PC‐1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients