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Transforming growth factor (TGF)-beta is a regulator of extracellular matrix accumulation. Both TGF-beta receptors, type I (TbetaRI) and type II (TbetaRII), may be required for signal transduction in the TGF-beta pathway. The aim of this study was to investigate the relationship between the TGF-beta pathways and glomerular basement membrane (GBM) accumulation in vivo.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

Immunoelectron microscopic study on type I, II and III TGF-β receptors on visceral glomerular epithelial cells in relation to glomerular basement membrane alterations in proteinuric rats