Open AccessEndothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases
Author(s) -
Ying Wang,
Shuichi Kikuchi,
Hiromichi Suzuki,
Sohji Nagase,
Akio Kôyama
Publication year - 1999
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/14.12.2898
Subject(s) - diabetic nephropathy , medicine , nitric oxide synthase , nephropathy , endocrinology , renal function , nitric oxide , diabetes mellitus , genotype , intron , agarose gel electrophoresis , kidney disease , gene , biology , genetics
Nitric oxide is a very potent regulator of intrarenal haemodynamics and is thought to be an important factor in the deterioration of renal function. Our study sought to verify the hypothesis that endothelial nitric oxide synthase (ecNOS) gene polymorphism in intron 4 might have some relevance to progression in chronic renal failure.
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