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257 hepatitis C and D virus in screened blood units. 11th World (UBI HCV EIA 4.0, Organon) and those found positive were re-evaluated by line immune assay (LiaTek HCV III, 1996. Abstract Organon). Thirty-three (31.4%) patients were anti-HCV and 26 (24.7%) patients were HCV-RNA positive. The prevalence Diagnosis of human immunodeficiency virus type 1 and 2 in a of HCV-Ab was remarkably lower (6.8%) among CAPD Turkish blood donor population. patients, compared to the HD group (45.7%). The duration of dialysis, the number of transfused patients and the average number of blood units received by each transfused patient were significantly higher in HD group that could explain the IGFBP-3 on serum levels in children with ESRD higher prevalence. Other variables associated with HCV infection in HD group were the duration of the dialysis and renal tx history. There was a significant relation between Sir, Growth retardation is an important consequence of end HCV-Ab positivity and the elevated ALT levels in both study groups. None of the HCV-Ab negative patients had ALT stage renal disease (ESRD) in childhood. There have been several reports on the role of growth hormone (GH) and elevations in the past 3 months prior to the study in HD group. There was no significant relation between hypertrans-GH-related growth factors such as insulin-like growth factor (IGF-I) in ESRD [1–3]. GH binds to the GH binding aminasaemia and HCV viraemia among HCV-Ab positive patients. protein (GHBP), a 60 kDa protein, and forms a 85 kDa complex in serum. About 50% of the GH in serum is present Blood and blood products are important factors in the transmission of HCV infection. The HCV-Ab positivity rate in this form [4]. The 60 kDa GHBP is identical to the extracellular domain of the GH receptor that mediates of the blood donors in the same institute was found to be 0.6% in a previous study [3]. This route of transmission normal GH action. IGF-I is bound to specific binding proteins in the circulation. In human serum, IGFBP-3, a became relatively unimportant since October 1996, when HCV screening of blood donors became compulsory in 150 kDa glycoprotein complex, was found to be the predominant protein, binding >95% of IGF-I. In uremia, there is Turkey. Many investigators stress the importance of strict applications of universal precautions to prevent HCV infec-an excess of IGFBP-3, with molecular fragments of 12–150 kDa, caused by reduced renal clearance. IGFBP-3 …

Influence of peritoneal loss of GHBP, IGF-I and IGFBP-3 on serum levels in children with ESRD