Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria | Zendy

Marie Hébert | Zendy; Tomoko Takano | Zendy; A Papayianni | Zendy; Helmut G. Rennke | Zendy; Andrew W. Minto | Zendy; David J. Salant | Zendy; Michael C. Carroll | Zendy; Hugh R. Brady | Zendy

Open Access

Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria

Author(s) -

Marie Hébert,

Tomoko Takano,

A Papayianni,

Helmut G. Rennke,

Andrew W. Minto,

David J. Salant,

Michael C. Carroll,

Hugh R. Brady

Publication year - 1998

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/13.11.2799

Subject(s) - medicine , proteinuria , nephrotoxicity , nephritis , immunology , complement (music) , complement system , kidney , antibody , phenotype , gene , genetics , complementation , biology

The importance of complement in the pathophysiology of renal disease is still being appreciated. To further address the role of this mediator system, we evaluated the influence of absolute deficiency of C3 and C4 on acute nephrotoxic serum nephritis (NSN).

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