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Reactive oxygen species (ROS) are considered to have a role in the progression of puromycin aminonucleoside (PAN) nephrosis. However, the exact mechanism by which PAN induces ROS in this model is little known. In the present study, we attempted to purify a candidate for the target protein from PAN nephrotoxicity.

Purification and localization of a 25-kD porcine renal puromycin aminonucleoside-binding protein