Open AccessReceptor-mediated lipoprotein uptake by human glomerular cells: comparison with skin fibroblasts and HepG2 cells
Author(s) -
Thomas Quaschning,
M. Königer,
Annette KrämerGuth,
S. Greiber,
Hermann Pavenstädt,
Markus Nauck,
P. Schollmeyer,
C. Wanner
Publication year - 1997
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.12.2528
Subject(s) - very low density lipoprotein , medicine , endocrinology , ldl receptor , receptor , lipoprotein , mesangial cell , podocyte , chemistry , biology , kidney , cholesterol , proteinuria
Currently the mechanisms of glomerular lipid accumulation are not completely understood. The present study characterizes the mechanisms of lipid uptake by glomerular cells. Since renal diseases are frequently associated with an accumulation of apoE-containing triglyceride-rich lipoproteins, we were interested to investigate whether glomerular epithelial or mesangial cells possess VLDL receptors besides the well established LDL receptors.
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