Open AccessStructure analysis of oligonucleotide in organic solvent
Author(s) -
Hiroshi Abe,
Naoko Abe,
Yoshihiro Ito
Publication year - 2006
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrl013
Subject(s) - oligonucleotide , solvent , organic solvent , chemistry , polar , molecule , organic molecules , dichloroethane , combinatorial chemistry , catalysis , oligomer restriction , dna , organic chemistry , chemical engineering , biochemistry , physics , astronomy , engineering
Oligonucleotide has been used as functional molecule such as recording device, or catalyst for chemical reaction. However, that utility has been limited, because it is only soluble in water. Recently, we succeeded in making chemically modified DNA which is clearly soluble in organic solvent. Using this technique, G-quadruplex was constructed in non-polar organic solvent such as 1,2-dichloroethane. The structure was analyzed by CD spectra.
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