Synthesis and properties of the aromatic clusters arrayed along DNA strands

Functional groups arrayed along DNA strands have been expected to show unique properties that are different from those monomers. Oligonucleotides carrying multi-pyrene groups arrayed along DNA strands showed strong excimer fluorescence emission intensities. The oligonucleotides carrying pyrene groups are surmised to be in single stranded forms in solutions. On the other hand, oligonucleotides carrying methyl red groups formed double stranded forms in which methyl red groups were tightly stacked. The structural factors which control the single strand-double strand equilibriums will be discussed.