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Genetic predisposition has been implicated in the development of coronary heart disease (CHD). We made a molecular scanning of several genetic polymorphisms to see whether they are associated with CHD in Japanese patients with type 2 diabetes mellitus. Among several polymorphisms, only a polymorphism of paraoxonase gene was confirmed to be associated with CHD in this population. This polymorphism seems to be important in the development of CHD in Japanese as well as in Caucasian population.

Molecular scanning of susceptibility genes for the development of coronary heart disease in Japanese