Open AccessSynthesis of oligodeoxyribonucleotides bearing a functional group at 2'-position by post-synthetic modification
Author(s) -
Hiroaki Ozaki,
Shingo Momiyama,
Kazuyuki Yokotsuka,
H. Sawai
Publication year - 1999
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/42.1.47
Subject(s) - derivative (finance) , functional group , chemistry , deoxyuridine , thio , stereochemistry , bearing (navigation) , group (periodic table) , position (finance) , combinatorial chemistry , biochemistry , organic chemistry , dna , computer science , polymer , finance , artificial intelligence , financial economics , economics
A novel 2'-thio-2'-deoxyuridine derivative bearing a reactive ester at 2'-position was synthesized and incorporated into oligodeoxyribonucleotides (ODNs) for the post-synthetic modification of ODNs. This ODNs was reacted with several amines to give ODNs having a functional group at 2'-position.
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