Open AccessArtificial DNAs with metal-assisted base pairs
Author(s) -
Kentaro Tanaka,
H.T. Cao,
Masao Tasaka,
Mitsuhiko Shionoya
Publication year - 1999
Publication title -
nucleic acids symposium series
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/42.1.111
Subject(s) - nucleobase , moiety , catechol , oligonucleotide , metal , chemistry , chelation , combinatorial chemistry , base (topology) , base pair , stereochemistry , base metal , dna , organic chemistry , biochemistry , materials science , mathematics , metallurgy , mathematical analysis , welding
Two types of artificial beta-C-nucleosides, 2 and 3, were newly synthesized, which possess a metal chelating site (2-aminophenol and catechol, respectively) at the nucleobase moiety. These nucleosides are expected to form metal-assisted base pairs in oligonucleotides and thereby to control high-order structures and functions of DNAs.
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