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Trinuclear Cu(II) complex of N,N,N',N',N",N"-hexa[(2-pyridyl)methyl]-1,3,5-tris(aminomethyl)benzene (L3A) exhibits remarkable substrate-specificity for hydrolysis of 2'--&gt;5' and 3'--&gt;5' ribonucleotides. Up(2'--&gt;5')U is hydrolyzed much efficiently than is Up(3'--&gt;5')U, but Ap(3'--&gt;5')A is overwhelmingly preferable to Ap(2'--&gt;5')A.

Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA