Open AccessLinker chain effect of ferrocenyl naphthalene diimide on a double stranded DNA preference
Author(s) -
S. Sato,
Hiroshi Takamiya,
Kenichi Yamashita,
Makoto Takagi,
H. Kondo,
Shigeori Takenaka
Publication year - 2001
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/1.1.269
Subject(s) - linker , naphthalene , diimide , dna , chemistry , ligand (biochemistry) , derivative (finance) , electrochemistry , photochemistry , stereochemistry , organic chemistry , perylene , biochemistry , molecule , electrode , financial economics , computer science , operating system , receptor , economics
Naphthalene diimide derivative 1 carrying two 3-(ferrocenyl-methylamino)-propyl substituents was synthesized as a new hybrid indicator for electrochemical gene sensing. Ligand 1 showed a preference for double stranded DNA four-times larger than 2 previously described. The peak potential of 1 shifted 30 mV toward the negative side from that of 2, thereby shortening the time required for gene detection.
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