Open AccessSynthetic study of guanofosfocin. Synthesis of 8-(mannopyranosyloxy)inosine derivative
Author(s) -
Wataru Kiyohara,
Y. Natsui,
Akito Koizumi,
Hideyuki Sugimura
Publication year - 2001
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/1.1.183
Subject(s) - glycosylation , mitsunobu reaction , inosine , chemistry , combinatorial chemistry , nucleoside , derivative (finance) , bromide , stereochemistry , organic chemistry , biochemistry , enzyme , financial economics , economics
As a basic study directed towards the synthesis of guanofosfocin analogues, preparation of a new class of nucleoside-carbohydrate hybrid has been investigated by two approaches; (1) glycosylation of 8-oxoinosine derivatives with mannopyranosyl bromide and (2) Mitsunobu reaction of 8-oxoinosine derivatives with protected mannopyranoses.
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