English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Current evolutionary scenarios posit the emergence of  Mycobacterium tuberculosis  from an environmental saprophyte through a cumulative process of genome adaptation.  Mycobacterium riyadhense , a related bacillus, is being increasingly isolated from human clinical cases with tuberculosis-like symptoms in various parts of the world. To elucidate the evolutionary relationship between  M. riyadhense  and other mycobacterial species, including members of the  M. tuberculosis  complex (MTBC), eight clinical isolates of  M. riyadhense  were sequenced and analyzed. We show, among other features, that  M. riyadhense  shares a large number of conserved orthologs with  M. tuberculosis  and shows the expansion of toxin/antitoxin pairs, PE/PPE family proteins compared with other non-tuberculous mycobacteria. We observed  M. riyadhense  lacks  wecE  gene which may result in the absence of lipooligosaccharides (LOS) IV. Comparative transcriptomic analysis of infected macrophages reveals genes encoding inducers of Type I IFN responses, such as cytosolic DNA sensors, were relatively less expressed by macrophages infected with  M. riyadhense  or  M. kansasii , compared to BCG or  M. tuberculosis . Overall, our work sheds new light on the evolution of  M. riyadhense , its relationship to the MTBC, and its potential as a system for the study of mycobacterial virulence and pathogenesis.

Insights into the ancestry evolution of theMycobacterium tuberculosiscomplex from analysis ofMycobacterium riyadhense