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Histone H1o is an H5-like protein found in mammals. Its location in chromatin from animal tissues has been studied by micrococcal nuclease digestion and by quantitation. It was found that H1o occurs in the linker region of chromatin, and replaces H1 there as it does so. As much as a third of the H1 becomes replaced, at least in some tissues. The abundance of H1o was similar in bulk chromatin and in a mononucleosome population which was putatively enriched in transcribed DNA sequences. It was concluded that H1o probably does not suppress transcription.

Histone H1O: its location in chromatin

Histone H1^O: its location in chromatin