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All DNA polymerases known to date are classified into three families, based on evolutionary relatedness (1). The E.coli DNA polymerase I and the 77 phage DNA polymerase share sequence similarity for regions including DNA binding domain (2) and are classified as family A (1). Family B includes cellular and DNA virus polymerases of eukaryotes as well as polymerases of some bacteriophages including T4, <p29 and PRD1 (1,3). Members of this family show considerable similarity to each other, but show no appreciable similarity with those of the family A (1). Bacteriophage SPO2 DNA polymerase (4), designated family C, was thought to have no similarity with polymerases of both the family A and the family B (1). We found that the SPO2 DNA polymerase shares extensive similarities with E.coli and 17 polymerases for the DNA binding domain with 3 1 % and 19% identities, respectively. The probabilities that these similarities occur by chance are less than 1 0 ' 1 7 and 10'6, respectively (5), implying that the observed similarities are statistically significant and thus this DNA polymerase should be classified as a member of the family A.

Sequence similarity of bacteriophageSPO2 DNA polymerase withE.coliDNA polymerase I