Open AccessInhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia
Author(s) -
Yin Zhao,
Yanfang Zheng,
Xiaoxia Liu,
Qingqing Luo,
Di Wu,
Xiaoping Liu,
Li Zou
Publication year - 2018
Publication title -
molecular human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.143
H-Index - 122
eISSN - 1460-2407
pISSN - 1360-9947
DOI - 10.1093/molehr/gax068
Subject(s) - trophoblast , angiogenesis , preeclampsia , biology , placenta , decidua , thrombin , transfection , endocrinology , small hairpin rna , medicine , receptor , andrology , immunology , cell culture , fetus , cancer research , gene knockdown , pregnancy , platelet , biochemistry , genetics
Is it possible to improve vascular remodeling by inhibiting the excessive expression of protease-activated receptor 1 (PAR-1) in trophoblast of abnormal placenta?
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