Improved cryotolerance and developmental potential ofin vitroandin vivomatured mouse oocytes by supplementing with a glutathione donor prior to vitrification | Zendy

Tom Trapphoff | Zendy; Martyna Heiligentag | Zendy; Jenny Simon | Zendy; N. Staubach | Zendy; Thorsten Seidel | Zendy; Kathrin A. Otte | Zendy; Thomas Fröhlich | Zendy; Georg J. Arnold | Zendy; Ursula Eichenlaub-Ritter | Zendy

Open Access

Improved cryotolerance and developmental potential ofin vitroandin vivomatured mouse oocytes by supplementing with a glutathione donor prior to vitrification

Author(s) -

Tom Trapphoff,

Martyna Heiligentag,

Jenny Simon,

N. Staubach,

Thorsten Seidel,

Kathrin A. Otte,

Thomas Fröhlich,

Georg J. Arnold,

Ursula Eichenlaub-Ritter

Publication year - 2016

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gaw059

Subject(s) - germinal vesicle , biology , oocyte , glutathione , vitrification , in vitro maturation , andrology , cryopreservation , blastocyst , reproductive technology , microbiology and biotechnology , embryogenesis , embryo , biochemistry , enzyme , medicine

Can supplementation of media with a glutathione (GSH) donor, glutathione ethyl ester (GEE), prior to vitrification protect the mouse oocyte from oxidative damage and critical changes in redox homeostasis, and thereby improve cryotolerance?

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