Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme | Zendy

Polina V. Danshina | Zendy; Weidong Qu | Zendy; Brenda Temple | Zendy; Rafael J. Rojas | Zendy; Michael J. Miley | Zendy; Mischa Machius | Zendy; Laurie Betts | Zendy; Deborah A. O’Brien | Zendy

Open Access

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme

Author(s) -

Polina V. Danshina,

Weidong Qu,

Brenda Temple,

Rafael J. Rojas,

Michael J. Miley,

Mischa Machius,

Laurie Betts,

Deborah A. O’Brien

Publication year - 2016

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gaw016

Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , biology , dehydrogenase , glyceraldehyde , isozyme , enzyme , glycolysis , sperm , biochemistry , genetics

Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.

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