Open AccessTetanus–diphtheria–pertussis vaccine may suppress the immune response to subsequent immunization with pneumococcal CRM197-conjugate vaccine (coadministered with quadrivalent meningococcal TT-conjugate vaccine): a randomized, controlled trial⋆
Author(s) -
Mohamed Tashani,
Leon Heron,
Melanie Wong,
Harunor Rashid,
Robert Booy
Publication year - 2017
Publication title -
journal of travel medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.985
H-Index - 59
eISSN - 1708-8305
pISSN - 1195-1982
DOI - 10.1093/jtm/tax006
Subject(s) - medicine , tetanus , pneumococcal conjugate vaccine , diphtheria , vaccination , toxoid , polyvalent vaccine , immunization , meningococcal vaccine , conjugate vaccine , immunology , diphtheria toxin , streptococcus pneumoniae , immune system , microbiology and biotechnology , toxin , antibiotics , biology
: Due to their antigenic similarities, there is a potential for immunological interaction between tetanus/diphtheria-containing vaccines and carrier proteins presented on conjugate vaccines. The interaction could, unpredictably, result in either enhancement or suppression of the immune response to conjugate vaccines if they are injected soon after or concurrently with diphtheria or tetanus toxoid. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage of 2015.
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