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The aim of this study was to investigate the feasibility and sensitivity of using individual volume-based 3D gamma indices for composite dose-volume histogram (DVH)-based intensity-modulated radiation therapy (IMRT) quality assurance (QA). Composite IMRT QA for 15 cervical cancer patients was performed with ArcCHECK. The percentage dosimetric errors (%DEs) of DVH metrics when comparing treatment planning system and QA-reconstructed dose distribution, percentage gamma passing rates (%GPs) with different criteria for individual volumes and global gamma indices were evaluated, as well as their correlations. Receiver operating characteristic (ROC) curves were applied in order to study the sensitivities of the global and individual volume gamma indices. Most %DEs of the DVH metrics were within 3%. The γPTV and γrectum were &lt;80% at 2%/2 mm; apart from these two individual volume indices, all other individual volume gamma indices and global indices had acceptable %GPs. For the criteria of 2%/2 mm, 3%/3 mm and 4%/4 mm, individual volume-based %GPs and global %GPs were correlated in 11, 1 and 12 out of 24 %DE metrics, and in 5, 4 and 5 out of 24 %DE metrics, respectively. Individual volume-based %GPs had a higher percentage of correlation with DVH metrics (%DEs) compared with global %GPs in composite IMRT QA. The areas under the curve (AUCs) of individual volume %GPs were higher than those of global %GPs. In conclusion, individual volume-based %GPs had a higher correlation with %DEs of metrics and a higher sensitivity presented by ROC analysis compared with global %GPs for composite IMRT QA. Thus, use of individual volume-based 3D gamma indices was found to be feasible and sensitive for composite IMRT QA.

Composite QA for intensity-modulated radiation therapy using individual volume–based 3D gamma indices